By Dr. Priyom Bose, Ph.D.Jan 2 2023Reviewed by Aimee Molineux Unvaccinated individuals exhibit significant clinical variability during primary infection with severe acute respiratory syndrome coronavirus 2 , which is the causal agent of the ongoing coronavirus disease 2019 pandemic. Notably, common genetic factors serve as modest risk factors for disease progression.
During the early phase of the disease, children with MIS-C do not typically exhibit viral infection in the upper respiratory tract or manifest symptoms related to hypoxemic pneumonia. The majority of MIS-C patients test positive for anti-SARS-CoV-2 antibodies. The clinical features of MIS-C in children include rash, coronary aneurysm, elevated biological markers of acute inflammation, abdominal pain, fever, myocarditis, and lymphadenopathy.
About the Study A total of 558 MIS-C patients were enrolled in this study. The participants originated from Europe, Asia, Africa, and America. Five MIS-C patients from the study cohort were selected, and they were designated as P1 , P2 , P3 , P4 , and P5 . Among these five patients, two were boys, and three were girls between 3 months and 14 years of age at the time of diagnosis.
mRNA sequencing of the blood samples collected from P1 and P2 indicated unique transcriptomic signatures that differed from the healthy control group and children with acute COVID-19 pneumonia. However, these transcriptomic signatures were found to be similar to previously reported MIS-C patients.
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