bacterium. This bacterium was long carried by fleas that feasted on black rats. When rat colonies diminished, the fleas jumped to humans to feed. Plague outbursts persisted for centuries, including one in 1665 in the. The village went into quarantine and lost 47 percent of its population in 14 months.
In order to determine whether a gene mutation was at play, researchers needed DNA samples from people who died before, during and after the plague. The during-the-plague sample had already been identified after scientists in the The team divided the DNA samples into three categories. The first group lived prior to the Black Death. For London, the burials occurred between the years 1000 and 1250. In Denmark, the death dates ranged from 850 to 1350.
In all, the team collected 516 DNA samples — 318 from London and 198 from Denmark. As one might expect with remains almost a millennium in age, the DNA was not well-preserved. The team, however, was able to use hybridization capture to enrich and sequence hundreds of immune-related genes.
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