Drug Discovery: Existing Medicines May Treat a Common Kidney Disease

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New research findings reveal that a serious condition that can cause the kidneys to suddenly stop working could be treated with existing medicines. Scientists found that medicines usually used to treat angina and high blood pressure prevented much of the long-term damage to the kidney and cardiov

According to a new study shows that a serious condition that can cause the kidneys to suddenly stop working could be treated with existing medicines.

Experts hope the findings will pave the way for improved treatment of AKI – a common condition that occurs in approximately 20 percent of emergency hospital admissions in the UK. Of those who survive an episode of AKI, 30 percent are left with chronic kidney disease . The remaining 70 percent that recover full kidney function are at an almost 30-fold increased risk of developing CKD. In time, CKD can result in kidneys that stop working altogether. This is known as kidney failure, end-stage renal disease , or end-stage kidney disease .

The mice were monitored over a four-week period after AKI. Those that were treated with the endothelin-blocking medicines had lower blood pressure, less inflammation and reduced scarring in the kidney.

 

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