Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae - Nature Medicine

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Transcriptomic analyses of acute-phase whole blood from a large cohort of patients with COVID19 identify molecular determinants of post-infection long-term sequelae LongCOVID SARSCoV2 noambeckmann1 aw_charney DarwinAwdWinner

. It is also anticipated that future studies of the relationship between acute infection and PASC will define additional symptom clusters with common underlying mechanisms. Finally, knowledge of symptom-specific mechanisms will present opportunities to investigate precision treatment and prevention strategies.This study was approved by the Human Research Protection Program at the Icahn School of Medicine at Mount Sinai .

The third approach to CDE ascertainment was a checklist of health changes after COVID-19 . The checklist was constructed when anecdotal reports of post-acute sequelae were just beginning to surface, with the goal of capturing a set of CDEs that collectively reflected the prevailing view of PASC at the time .

 

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noambeckmann1 aw_charney DarwinAwdWinner Researchers identify molecular determinants of post-infection long-COVID Coronavirus Disease COVID PASC LongCOVID IcahnMountSinai

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