Structural variants drive context-dependent oncogene activation in cancer - Nature

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Structural variants that modify chromatin structure are widespread in cancer genomes and contribute to oncogene activation NBThighlight

, Pie chart showing the fraction of intra-chromosomal vs. inter-chromosomal structural variant predictions., The number of observed intra-chromosomal or inter-chromosomal rearrangements identified in each cell line. for the observed frequency of intra-chromosomal rearrangements for each chromosome in each cell line under the null hypothesis that rearrangements are randomly distributed across chromosomes.

, Violin plots showing the distribution of the frequency of enhancers in domains that show TAD fusion events versus those that do not . P-value is calculated from the two-sided Wilcoxon Rank Sum test., Bar plots showing the percentage of domains that contain super enhancers for domains that contain TAD fusion events or do not . The domain/super-enhancer analysis was performed for each domain in each cell type. P-value is calculated by Fisher’s exact test.

 

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