By Pooja Toshniwal PahariaDec 7 2022Reviewed by Aimee Molineux In a recent study published in the American Journal of Respiratory and Critical Care Medicine, researchers identified risk factors for and the prevalence of persistent pulmonary tissue alterations among hospitalized coronavirus disease 2019 patients.
The present interim analysis used PHOSP-COVID data obtained within eight months of hospital discharge. Thoracic PHOSP-COVID study identifiers-linked computed tomography scans were allotted scores based on the percentages of residual pulmonary pathologies such as reticulations and ground glass opacifications. The team estimated risk factors on the CT scans by Bayesian binomial regression modeling.
The percent predicted values for diffusion capacity for carbon monoxide across lungs and the forced vital capacity were evaluated. Linear mixed effects modeling was performed to analyze alterations in the residual pulmonary pathologies with time, and risk ratios were calculated. Residual pulmonary pathologies >10.0% were reported for 79% . On average, ground glass opacification, reticulation, and residual pathologies affected 26%, 15%, and 42% of the lungs. For 33 individuals, the scans were repeated after ≥90 days, 85% of whom showed residual pulmonary pathology >10.0% on the first scan, and 93% of them showed >10.0% pulmonary involvement in the second CT scan. The paired analysis showed an overall alteration in the residual pulmonary pathologies of -4.
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