, response evaluation was performed every six weeks during atezolizumab treatment or 12 weeks in patients with melanoma. The sum of longest diameter according to RECIST is the sum of the maximal diameter of target lesions, with short axis in the case of lymph nodes; best overall response is the most favorable response confirmed by a consecutive assessment.
Using data from study part A, postinjection time-uptake curves were fitted using postinjection imaging time point both categorically and continuously, selecting the best curve-fit for the latter from a linear, a log-linear or a quadratic fit using the Akaike’s Information Criterion . Protein dose level varied in part A and was included in these models as a main effect and using an interaction term with postinjection time.
For tumor uptake change during ICI therapy, we attempted to account for possible shrinkage of individual tumor lesions leading to an underestimation of actual uptake due to partial volume effects in a data-driven way. For this, we first assessed the relation between CT-measured tumor lesion volume and geometric meanZED88082A uptake in 238 lesions from 34 patients only using the treatment-naive measurements and using a 5-knot restricted cubic spline.
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