]. To reduce inter-study and even inter-session differences, headache-to-headache comparison between CH and migraine will be necessary, and these studies are still lacking. Furthermore, functional imaging studies investigating patients with CH are difficult to conduct because patients usually have restlessness during their attacks.
Although patients with CH and migraine share several specific treatment options, the mechanism or the site of action remains largely uncertain. Another critical question is whether drug response should be used to assist diagnose and classify headache disorders? Response to the drug has only been adopted as a diagnostic criterion in paroxysmal hemicrania and hemicrania continua. In addition, for any given medication, there are always clinical responders vs. clinical non-responders.
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