A study on Alzheimer's published recently by Yale University is quite attention-grabbing. Because the disease's crippling symptoms could be brought on by swelling in the brain brought on by amyloid plaques, say the experts.is the formation of amyloid plaques. Researchers have been trying to shrink these plaques in their researchers for years.
In mice with a condition similar to Alzheimer's disease, they discovered that removing PLD3 from neurons using gene therapy significantly decreased axonal swelling., and as a target for future therapeutics also Yale scientists herald. “It may be possible to eliminate this breakdown of the electrical signals in axons by targeting PLD3 or other molecules that regulate lysosomes, independent of the presence of plaques,” Grutzendler said.In vertebrates, an axon, also known as a nerve fiber, is a long, slender projection of a nerve cell, or neuron, that normally transports electrical impulses known as action potentials away from the nerve cell body.
Many inherited and acquired neurological illnesses that affect both peripheral and central neurons might be caused by axon malfunction.The precise mechanisms that lead to cognitive decline in Alzheimer’s disease are unknown. Here we identify amyloid-plaque-associated axonal spheroids as prominent contributors to neural network dysfunction.
JeffEdwardsMSRD
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