Outcomes of malignancy in adults with congenital heart disease: a single center experience - Cardio-Oncology

  • 📰 BioMedCentral
  • ⏱ Reading Time:
  • 10 sec. here
  • 2 min. at publisher
  • 📊 Quality Score:
  • News: 7%
  • Publisher: 71%

Health Health Headlines News

Health Health Latest News,Health Health Headlines

In Adult Congenital Heart Disease (ACHD) patients with cancer, most deaths occur due to cancer despite significant ACHD complexity and baseline cardiovascular risk, reports a study published in Cardio-Oncology.

]. Exclusion criteria included non-malignant neoplasms, heart transplantation prior to cancer diagnosis, and lack of CHD. Patent foramen ovale was not considered as CHD.Clinical data were obtained from our electronic medical record and external facilities when available, and supplemented by correspondence with patients, families and treating physicians when needed. Only patients who had consented to use their records for medical research were included in this study.

Cancer-related data obtained included age, primary location and stage at diagnosis and details of cancer therapy, including doses of known cardiotoxic therapies if available.

 

Thank you for your comment. Your comment will be published after being reviewed.
Please try again later.

datsunian KimYanMD Bravo__MD

We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:

 /  🏆 22. in HEALTH

Health Health Latest News, Health Health Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

Local cancer charity’s static caravan boost for young hospital patientsA Shropshire children’s cancer charity has raised an extraordinary £70,000 to fund a static caravan to offer breaks to local families whose child is being cared for by the Children’s Oncology Ward at The Princess Royal Hospital, Telford.
Source: shropshirelive - 🏆 55. / 63 Read more »

The role of school connectedness in the prevention of youth depression and anxiety: a systematic review with youth consultation - BMC Public HealthBackground School connectedness reflects the quality of students’ engagement with peers, teachers, and learning in the school environment. It has attracted attention from both the health and education sectors as a potentially modifiable protective factor for common mental health problems. However, the extent to which school connectedness may prevent the onset of youth depression or anxiety or promote their remission is unclear. This systematic review examined evidence for prospective relationships between school connectedness and depression and anxiety, and the effect of interventions to improve school connectedness on depression and anxiety. Methods We searched MEDLINE, PsycINFO, PubMed, and ERIC electronic databases for peer-reviewed quantitative longitudinal, or intervention studies published from 2011–21 in English examining relationships between school connectedness and anxiety and/or depression. Participants were 14–24 years old when depression and anxiety outcomes were assessed in any education setting in any country. We partnered with five youth advisers (aged 16–21 years) with lived experience of mental health problems and/or the schooling system in Australia, Indonesia, and the Philippines to ensure that youth perspectives informed the review. Results Our search identified 3552 unique records from which 34 longitudinal and 2 intervention studies were ultimately included. Studies were primarily from the United States of America (69.4%). Depression and anxiety outcomes were first measured at 14 years old, on average. Most studies found a significant protective relationship between higher levels of school connectedness and depressive and/or anxiety symptoms; more measured depression than anxiety. A few studies found a non-significant relationship. Both intervention studies designed to increase school connectedness improved depression, one through improvements in self-esteem and one through improvements in relationships at school. Conclusions These findings su
Source: BioMedCentral - 🏆 22. / 71 Read more »

CAR-T cell combination therapy: the next revolution in cancer treatment - Cancer Cell InternationalIn recent decades, the advent of immune-based therapies, most notably Chimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer treatment. The promising results of numerous studies indicate that CAR-T cell therapy has had a remarkable ability and successful performance in treating blood cancers. However, the heterogeneity and immunosuppressive tumor microenvironment (TME) of solid tumors have challenged the effectiveness of these anti-tumor fighters by creating various barriers. Despite the promising results of this therapeutic approach, including tumor degradation and patient improvement, there are some concerns about the efficacy and safety of the widespread use of this treatment in the clinic. Complex and suppressing tumor microenvironment, tumor antigen heterogeneity, the difficulty of cell trafficking, CAR-T cell exhaustion, and reduced cytotoxicity in the tumor site limit the applicability of CAR-T cell therapy and highlights the requiring to improve the performance of this treatment. With this in mind, in the last decade, many efforts have been made to use other treatments for cancer in combination with tuberculosis to increase the effectiveness of CAR-T cell therapy, especially in solid tumors. The combination therapy results have promising consequences for tumor regression and better cancer control compared to single therapies. Therefore, this study aimed to comprehensively discuss different cancer treatment methods in combination with CAR-T cell therapy and their therapeutic outcomes, which can be a helpful perspective for improving cancer treatment in the near future.
Source: BioMedCentral - 🏆 22. / 71 Read more »