and the American College of Cardiology/American Heart Association CVD risk score algorithms have already been evaluated in UKB. The published C-statistics for these three risk scores were 0.77, 0.74 and 0.74, respectively, with 95% CI that overlap with values for the simpler RV model presented in this study. However, the novel C-statistics for circulatory mortality reported in this study are higher.
UKB and EPIC-Norfolk are ‘healthy’ cohorts with relatively low event rates compared with other geographically similar middle-aged cohorts.Prevalence of current smoking was very low in UKB and limited the ability to examine interactions with RV. Although we did not find limiting the analysis to those of white ethnicity materially altered the results, the proportion of non-white participants in UKB is low.
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