— TNS
Dr Ahn worked with UT Southwestern Medical Center professor Dr Ganesh Raj and Ratna Vadlamudi from the University of Texas Health Science Center at San Antonio on the research. Triple-negative breast cancer, or TNBC, is an aggressive form of breast cancer that comprises about 15% of new breast cancer diagnoses.
The researchers altered the molecule’s structure and tested it on breast cancer cells, using TNBC cells as a baseline. They weren’t expecting it to work on the TNBCs – after all, the molecule wasn’t designed to kill those cells. Healthy cells have less LIPA compared to TNBC cells. The researchers found that ERX-41 successfully killed human cancer cells in mice without significantly harming healthy cells.
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