Study reveals the heavy burden of RSV among healthy infants

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Study reveals the heavy burden of RSV among healthy infants Bronchopulmonary Dysplasia Children Respiratory RespiratorySyncytialVirus Virus Virology RSV LancetRespirMed

By Suchandrima BhowmikNov 14 2022Reviewed by Emily Henderson, B.Sc. Worldwide, respiratory syncytial virus causes a significant burden of disease among infants. According to estimates, more than 101,000 children under five die every year. Although more than 97% of RSV-related deaths occur in low and middle-income countries, the RSV healthcare burden is also quite significant in high-income countries.

The study also estimated the incidence of symptomatic RSV infections, the proportion of respiratory infections caused due to RSV, and the incidence of all-cause respiratory infections. During enrolment, the birth cohort participants were invited to be a part of a nested cohort, also referred to as an active surveillance cohort. Each site was recommended to recruit 15 to 20 participants per week to have a cohort with even distribution of months and years of birth. Enrolment in the active surveillance cohort continued until the number of participants reached 200 per site.

The incidence rate of RSV-associated hospitalization was observed to be higher in children born in autumn compared to those born in winter and spring. The incidence rate was observed to be highest in 2017–18 and lowest in 2019–20. In addition, 84 out of the 145 RSV-associated hospitalizations were reported in children younger than three months. The median duration of hospitalization was reported to be three days and was longer in Spain than in other countries.

 

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