More than half of the children treated saw a greater than 75% reduction in symptoms.found that dupilumab was highly effective in reducing the signs and symptoms of moderate-to-severe. This is the first study to treat moderate-to-severe eczema in infants and children 6 months to 5 years of age with a biologic drug instead of immune-suppressing medications.
Eczema, also known as atopic dermatitis, is a chronic inflammatory skin condition that causes itching and red, dry, often oozing, skin. It can have a significant impact on the life of both the patient and their family. “The ability to take this drug will significantly improve the quality of life for infants and young children who suffer tremendously with this disease,” Paller said. “Atopic dermatitis or eczema is so much more than just itchy skin. It is a devastating disease. The quality of life of severe eczema — not only for the child but also parents — is equivalent to many life-threatening diseases.”
“Up to now, all we have had to treat more severe eczema is immune-suppressing medications, such as oral steroids, which we try to avoid in children because they are associated with so many side effects and thus are not a preferred treatment for a chronic skin disease,” Paller said. “The potential long-term impact on the development of the immune system in young children is also of concern with these immunosuppressants.
In fact, 66% of children in this trial had developed their eczema during the first six months of life and, by the time of initiating the dupilumab, more than 80% had already developed at least one allergic disorder, such as asthma or food allergy.
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