The landscape of mRNA nanomedicine - Nature Medicine

, Self-circularization of the linear RNA precursor is initiated by the circularization ribozyme, resulting in the RNA intermediates. The subsequent RNA splice yields the final highly stable circRNA containing an IRES for driving protein expression., An endless RNA developed by Laronde could have long-lasting protein translation by using an optimized IRES.

, A novel fusogenix proteo-lipid vehicle platform comprising neutral lipids and proprietary fusion-associated small transmembrane protein enables direct cytosolic mRNA delivery., A SORT nanoparticle platform prepared by adding a supplemental SORT molecule of cationic, anionic or ionizable lipid to a conventional LNP system allows selective delivery of mRNAs to the lung, spleen or liver, respectively.

kochinstitute WeiTaoLab harvardmed MIT It’s time we invested in a scalable solution that targets mucosal immunity that could prevent infection & transmission! It would be easy, cheap, safe & more effective to ship & deliver billions of Vaxart Covid19 💊 vaccines & boosters to everyone.

kochinstitute WeiTaoLab harvardmed MIT nature? hmmmm medicine? hmmmm nature medicine? mrna nanomedicine - how nature?

kochinstitute WeiTaoLab harvardmed MIT The perspective of nanomedicine is great anyway. The mRNA technology had been used for cancer treatments for several years. As for vaccine production, is still young, first-generation! Impartiality! A lot of room for research

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