A recent study reveals how Parkinson’s spreads throughout the brain.scientists, aggregates of the protein alpha-synuclein spread in the brains of Parkinson’s disease patients through a cellular waste-ejection process.
“Our results also suggest that lysosomal exocytosis could be a general mechanism for the disposal of aggregated and degradation-resistant proteins from neurons—in normal, healthy circumstances and in neurodegenerative diseases,” said study senior author Dr.
Lysosomes contain enzymes that can break down, or “lyse,” proteins and other molecular waste into their building blocks, essentially digesting and recycling them. But the researchers found evidence that alpha-synuclein aggregates, which are knit together with tight bonds in a close-fitting/snugly layered structure called “amyloid”, are not broken down well within lysosomes; instead, they were often found to be simply dumped from their originating neurons.
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