Frontiers | Using phenome-wide association studies and the SF-12 quality of life metric to identify profound consequences of adverse childhood experiences on adult mental and physical health in a Northern Nevadan population

). Both components must be included to produce a reliable risk assessment for health outcomes. Previous research by Schlauch et al. used an interaction model to examine the effect of ACEs and genetics on BMI and found the phenotypic effect of ACEs be strengthened for those carrying specific germline genetic variations .

The sample size of the cohort is somewhat prohibitive when studying rarer disorders and/or high ACE exposure; the HNP is continuously growing, thus this restriction will likely be relieved.The data analyzed in this study are subject to the following licenses/restrictions: These data are available to qualified researchers upon reasonable request and with permission of the Center for Genomic Medicine.

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