at the National Institutes of Health in Maryland and their colleagues first gave water containing nicotine to six mice with gut bacteria and six mice without gut bacteria to compare how they were affected. In mice without gut bacteria, the levels of nicotine in the gut were higher than in mice with such bacteria.that could degrade nicotine in a lab dish using an enzyme called NicX.
To see if the microbe could reduce the severity of non-alcoholic fatty liver disease, the researchers fed 12 further mice with gut bacteria a diet high in sugar and cholesterol along with water containing nicotine for 20 weeks to induce the condition. Some of the mice were also given a dose ofevery three days via a tube into the stomach, and these mice had roughly half as much nicotine in their intestines.
What’s more, the livers of mice given the bacterium had less scarring and inflammation than other mice, suggesting the microbe counteracted nicotine’s harmful effects.The researchers also analysed stool samples from 41 smokers with non-alcoholic fatty liver disease, and found that people with higher levels ofSun suggests that a probiotic containing the NicX enzyme could be developed for use in people, to decrease nicotine levels and ward off fatty liver disease.
However, more research is needed to see if this would work and it shouldn’t be seen as a way to keep smoking, says Gonzalez. “It’s very hard to actually alter the human microbiome long term, limiting such an approach,” he says.
Study paid for by the tobacco industry.
Yeah mum.
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Source: NatureMedicine - 🏆 451. / 53 Read more »