at a starting dose of 0.5 mg/kg, each one lasting around 40 minutes. Half of the patients responded to treatment within six weeks, and 20% reported remission of their depression symptoms. During the same period, 50% of patients with self-harm/suicidal ideation reported entering remission or had fewer symptoms. One-third of patients reported decreased anxiety symptoms.
“The high rates of response and remission were similar to those for interventional treatments in community samples of TRD,” researchers wrote. However, they acknowledged several limitations of the study, which included no control group and used self-reported patient data. “Comparative efficacy trials with other interventions and randomized controlled trials ofRoberto Olivardia, Ph.D.
“The drug, still considered experimental, is used for severe cases of treatment-resistant depression,” he continued. “When other antidepressant medications have failed, or if there’s acute suicidality, ketamine infusions may be appropriate.” The U.S. Food and Drug Administration has not approved ketamine to treat psychiatric disorders. However, the “S” form of ketamine, which is derived from ketamine and known as Spravato , is a Schedule III controlled substance that was approved by FDA in 2019 as a nasal spray for treatment-resistant depression in adults and depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior, in conjunction with an oral antidepressant.Oliver, P. A., Snyder, A. D.
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