and insulin resistance in humans and rodents, broad anti-inflammatory treatments lack durable clinical efficacy on diabetes. In the current study, the researchers explored in more detail this association between inflammation and diabetes by looking for existing drugs that might affect both conditions.
The team evaluated the metabolic effects of auranofin in a mouse model of diabetes in which the animals consume a"We discovered that auranofin has anti-inflammatory and anti-diabetic effects that are independent from each other," said co-corresponding author Dr. Sean Hartig, associate professor of medicine-endocrinology, diabetes and metabolism and molecular and cellular biology at Baylor. Hartig also is a member of Baylor's Dan L Duncan Comprehensive Cancer Center.
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