By Pooja Toshniwal PahariaOct 14 2022Reviewed by Aimee Molineux In a recent review published in the Journal of Ginseng Research, researchers discussed the therapeutic potential of Panax ginseng for COVID-19 -induced neurological diseases.
About the review In the present study, researchers discussed existing literature concerning the SARS-CoV-2-induced neurodegeneration pathogenesis involving the activation of NLRP3 inflammasomes and the potential effectiveness of P. ginseng for NLRP3-targeted treatment of neurological diseases. In response to SARS-CoV-2-associated neurological injury and associated PAMP and DAMP formation, NLRP3 inflammasome is assembled and activated, stimulating the production of caspase-1-mediated interleukin -1β, IL-18, and other cytokines such as IL-6,12, and tumor necrosis factor-alpha by immunological cells. Therefore, NLP3 could be targeted to develop anti-SARS-CoV-2 therapeutic agents.
NLRP3 inflammasomes are initially expressed in inflammatory and immunological cells, including microglia, neutrophils, macrophages, and mast cells. Microglia are key cells involved in neuroinflammation, and balancing the M1/M2 microglia polarization is a potential therapeutic strategy for COVID-19-associated neurodegeneration.
The herb’s saponins inhibit NLRP3 and pro-IL-1β transcription and translation at the initial step. KRGE saponins have shown anti-inflammatory effects by ameliorating the messenger ribonucleic acid expression of genes encoding NLRP3 inflammasome components such as pro-IL-1β and pro-caspase-1 in mice. Ginsenoside Rd, a component of P.
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