]. Current guidelines reflect evidence that higher levels of protein delivery have been associated with positive patient outcomes in retrospective and prospective observational studies and small randomized controlled trials, which have not been definitively determined in adequately sized randomized controlled trials.
For instance, a double-blind, randomized trial found that a very high-protein enteral formula compared to a conventional, standard high-protein content formula demonstrated the ability to deliver adequate protein requirements without increased energy intake in critically ill patients who were overweight [A personalized approach to nutrition is key to delivering adequate protein while reducing the risk of excessive energy provision for critically ill patients with obesity to reduce morbidity and...
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