COVID-19 Linked to Increased Alzheimer's Risk

For the current study, researchers analyzed anonymous electronic health records of 6.2 million adults aged 65 years or older who received medical treatment between February 2020 and May 2021 and had no prior diagnosis of AD. The database includes data on almost 30% of the entire US population.The overall risk for new diagnosis of AD in the COVID-19 cohort was close to double that of those who did not have COVID .

After propensity-score matching, those who have had COVID-19 had a significantly higher risk for an AD diagnosis compared with those who were not infected . Risk for AD was elevated in all age groups, regardless of gender or ethnicity. Researchers did not collect data on COVID-19 severity, and the medical codes for long COVID were not published until after the study had ended."We expected to see some impact, but I was surprised that it was as potent as it was," Davis said.

"Because this study only showed an association through medical records, we cannot know what the underlying mechanisms driving this association are without more research," Snyder said."If you have had COVID-19, it doesn't mean you're going to get dementia. But if you have had COVID-19 and are experiencing long-term symptoms including cognitive difficulties, talk to your doctor.

Davis agreed, noting that this type of study offers information on association, but not causation."I do think that this makes it imperative that we continue to follow the population for what's going on in various neurodegenerative diseases," Davis said.and Alcoholism, the Clinical and Translational Science Collaborative of Cleveland, and the National Cancer Institute. Authors' disclosures are available in the original article. Synder reports no relevant financial conflicts.

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