Mucosal antibodies in the airways protect against omicron infection

High levels of mucosal antibodies in the airways reduce the risk of being infected by omicron, but many people do not receive detectable antibodies in the airways despite three doses of the SARS-CoV-2 vaccine. These are the findings of a study published today in The, led by researchers at Karolinska Institutet and Danderyd Hospital in Sweden.

The levels of mucosal IgA antibodies were measured in the airways because they play an important role in the protection against respiratory infections. All participants had high levels of systemic antibodies after three doses of the The researchers also showed that participants with SARS-CoV-2 infection prior to vaccination had significantly higher levels of mucosal airway antibodies after vaccination compared with triple-vaccinated with no prior SARS-CoV-2 infection. This may explain why so-called hybrid immunity, the combination of infection and vaccine, provides stronger protection against infection than just vaccines.

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