HEK293T cells were used for the assays, cultured in DMEM supplemented with 10% FBS . Cells were cultured in a humidified incubator maintained at 37 °C with 5% CO. Cells tested negative for mycoplasma based on the real-time PCR method at Eurofins GATC-Biotech . Identity of the HEK293T cells was confirmed by the Erasmus Molecular Diagnostics Department, using PowerPlex-16 STR genotyping .
PFS was defined as the time from anti-BRAF/EGFR therapy initiation to disease progression or death, whichever occurred first. OS was defined as the time from anti-BRAF/EGFR therapy initiation to death from any cause. PFS and OS were estimated using the Kaplan–Meier method and compared by the log-rank test. Cox proportional-hazard models were used to obtain HRs with 95% CIs. Formal statistical testing was only used in the validation cohort. No data imputation was performed.
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