]. Therefore, some patients with COVID-19 are expected to develop long-term neurocognitive sequelae after the acute disease has resolved. In general, the chronic cognitive sequelae of ischaemia and hypoxia can range from mild attention and memory impairment to general cognitive decline and dementia and even coma.Growing evidence suggested that survivors of COVID-19 suffer from neurological involvement. The brain is undoubtedly one of the targets of COVID-19.
Notably, it is important for SARS-CoV-2 models to reliably test the molecular and functional consequences of infection and drug treatment strategies via the establishment of a high paracellular tightness in vitro that is comparable to physiological conditions in vivo. Currently, the link between BBB leakage and cognitive decline is poorly understood, and more research is needed to further define this link.
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