Supplementary folic acid associated with higher risk of COVID-19 diagnosis and mortality

Study: Folic acid and methotrexate use and their association with COVID-19 diagnosis and mortality: a case–control analysis from the UK Biobank. Image Credit: Pixel-Shot / Shutterstock

About the study The present study carried out a case-control analysis to determine the differential COVID-19 diagnosis and mortality risk associated with the use of folic acid supplements and methotrexate medications. The dataset obtained from the UK Biobank consisted of information from 380,380 participants who had been prescribed folic acid, methotrexate, anticonvulsants, iron supplements, and other medications such as statins.

Results The study results indicate a 1.5-fold increase in COVID-19 diagnosis risk and a 2.5-fold increase in COVID-19-related mortality risk associated with folic acid supplement prescriptions. Patients on prescribed methotrexate and folic acid supplements were not at increased risk of COVID-19 diagnosis or death, indicating that methotrexate could play an antagonistic role against the deleterious effect of folic acid in COVID-19 patients.

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