The virology, epidemiology, transmission, clinical manifestations, diagnosis, management, and prevention strategies associated with monkeypox

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The virology, epidemiology, transmission, clinical manifestations, diagnosis, management, and prevention strategies associated with monkeypox MDPIOpenAccess nyuniversity monkeypox monkeypoxvirus virus

By Dr. Sanchari Sinha Dutta, Ph.D.Sep 6 2022Reviewed by Danielle Ellis, B.Sc. In a recent review article published in Venereology, scientists have described the epidemiology, transmission, clinical features, diagnosis, treatment, and preventive strategies of monkeypox infection among humans.

Monkeypox pathogenesis Monkeypox is a double-stranded DNA virus, and its genome is composed of 190 large non-overlapping open reading frames and structural proteins. The viral host cell entry process is initiated by the fusion of viral glycoproteins with host cell membrane glycosaminoglycans. About 95% of the recent infections have been detected in MSM and bisexual men. Another common finding among monkeypox-infected individuals is a positive status for human immunodeficiency virus .

Regarding vertical transmission, previous studies have indicated that the virus can adversely affect pregnancy, including congenital infection and severe maternal and fetal morbidity and mortality.

 

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