Plethysmographic measurements during both phases of the trial . Solid blue line shows proportion of participants who performed ≥1 measurement per week, dotted blue line shows proportion of participants who performed ≥2 measurements per week. The percentage refers to the total number of subjects assigned to digital screening according to the modified intention-to-treat principle.
. For this analysis only active participants performing at least one PPG-measurement during the entire study duration were considered . Two-sided p-values were calculated by means of Mann-Whitney U test; the exact p-value for; differences were considered statistically significant when the two-sided p-value was less than 0.05. There was no adjustment for multiple comparisons. Boxplots in show median and IQR.
Extended Data Fig. 6 Sensitivity of AF detection as function of PPG measurement frequency and AF burden. Model describing the weekly sensitivity for detecting atrial fibrillation as a function of the number of measurements per week and the AF-burden. We used the timestamps of the available 300,509 PPG-measurements in order to calculate the frequency of measurements for the various parts of the day. Based on this frequency pattern we subsequently simulated PPG-measurements for increasing AF-burden , which was defined as and finally calculated the sensitivity of the AF-detection.