, and other neurological and psychiatric conditions even after controlling for the main confounding risk factors, such as age and smoking," write Irina Odajiu, MD, of Colentina Clinical Hospital, Bucharest, Romania, and colleagues. However, data on the relationship between COPD and peripheral nervous system pathology are limited, they write.
"Additionally, in most presented studies, peripheral neuropathy correlated with disease duration and hypoxemia severity; the longer the duration and the more severe hypoxia, the more severe peripheral neuropathy was," the researchers note. Several strategies for managing peripheral neuropathy for patients with COPD were described. Prophylaxis options includewith hormones such as progesterone, neuronal growth factors, and corticosteroids, although none have shown high levels of effectiveness, the researchers write. Topical treatment with muscarinic antagonists has shown some potential and may be a practical therapeutic choice, they say.
"Moreover, the current data do not indicate a relationship between COPD stages, GOLD classification, or degree of obstruction and PNP," they say.
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