Can psilocybin combat mental health issues? How magic mushrooms show promise in fighting addiction.

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Research interest in psilocybin and other psychedelics has been growing, with studies exploring ketamine, MDMA, psilocybin and LSD, among others, to treat a wide range of conditions.

The psychedelic drug in"magic mushrooms" has been found to help treat anxiety and depression in cancer patients. The substance, psilocybin, also called shrooms, is illegal in the United States.Nicola d'Alessandro stopped drinking when she was 23. She stayed sober for 11 years until, as a young mom in suburban New York, she decided she was mature enough to drink socially again.The next few years she spent either downing a beer or thinking about when she could get the next one.

D'Alessandro spent close to a year seeing two different therapists who specialized in treating addictions. But that didn't make a dent in her drinking, nor did a stint in Alcoholics Anonymous. "There are people who just don't respond to conventional treatment and if this would help them that would be wonderful," Koob said."As the evidence mounts, which it is in a number of domains, we're definitely interested in supporting further study."in 2001-2002 to 12.9% a decade later and has likely kept rising since. Treatments aren't particularly effective, data shows.

Context matters, both Johnson and Bogenschutz said. A trip taken alone in a harsh environment might be destructive. At one point during the second psilocybin session, d'Alessandro said she became deeply afraid. She reached out to the therapist who took her hand, enabling her to feel calm and safe, allowing her"brain the freedom to do what it needed to do."

For the second session, her goal was to learn to remain sober."I just wanted to live differently, without this horrible poison ruining my life."Research into psychedelics took off during the 1950s and 1960s, but the field was discredited by its role in the counterculture. In 1970, psychedelics were classified as, meaning they were considered to have high abuse potential, no accepted medical use and were unsafe even under medical supervision.

Despite the public perception, psychedelics are not habit-forming, like heroin, cocaine, or alcohol, Bogenschutz said. An animal given the choice will not press a lever to get a second dose or hang out in the part of its cage where it thinks it'll get another hit."If anything, they're aversive" to repeated doses, he said.

The medication, Bogenschutz said, expands the ability of people to change, loosening the functional organization of their brain networks and opening up possibilities. Providing therapy helps people make use of that opportunity, he said.

 

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