Those who received the intradermal injection received one fifth of the subcutaneous dose, but produced similar levels of antibodies as those who received the original subcutaneous dose, according to a study published in 2015.
In recent weeks, both U.S. and EU regulators have backed the fractional dosing approach to stretch out scarce supplies. The feasibility of the approach will be evaluated at pilot clinics in Chelsea and Westminster NHS Trust, Central and North West London NHS Foundation Trust, and Locala Health and Wellbeing in Greater Manchester, the UK Health Security Agency said.
More than 40,000 confirmed cases of monkeypox – including a handful of deaths – in over 80 countries where the virus is not endemic have been reported since early May. Up to Aug. 15, there were nearly 3,100 confirmed cases in the UK. The UK has ordered 150,000 doses of the vaccine, a UKHSA spokesperson told Reuters earlier this month.Due to the limited vaccine stock, the post-exposure offer of vaccination is now being reserved for those close contacts who are at highest risk of severe illness, the UKHSA added on Monday.
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