Nanomedicine Specifically Targets Triple-Negative Breast Cancer

By Surbhi JainAug 23 2022Reviewed by Susha Cheriyedath, M.Sc. In an article recently published in the journal ACS Applied Bio Materials, researchers discussed the utility of neutrophil cell membrane coating of a self-assembly nanoconstruct to enable high specificity for triple-negative breast cancer treatment.

Nanotechnology in Medical Treatment The development of medication delivery systems based on nanotechnology has made considerable advancements in overcoming traditional constraints. Drug delivery methods based on nanoparticles have significantly advanced the field of cancer treatment. Biomimetic Nanoparticles for the Treatment of Triple Negative Breast Cancer In this article, the authors discussed developing a biomimetic NP construct with NPs encased in cell membranes that demonstrated a particular affinity for triple-negative breast cancer cells. The team created biomimetic supramolecular nanoconstructs with a core made of poly-tannic acid and biofunctionalized with neutrophil cell membranes .

Biological Characteristics of PVP-TA NPs The core of PVP-TA NPs coated with activated human neutrophil membranes was present, according to the analysis of PVT-NEU NPs. The study's findings supported PVTNEU NPs' increased targeting and engagement with tumor cells, which enhanced a model therapeutic agent's therapeutic activity.

Conclusions and Future Perspectives In conclusion, this study described the creation, improvement, and characterization of a biomimetic nanoconstruct that combined cell membrane properties and provided the NPs with a biological identity for treating breast cancer cells.

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