Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer’s disease - Nature Medicine

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A comprehensive comparison of AlzheimersDisease blood biomarkers in cognitively unimpaired individuals reveals that plasma p-tau231 and p-tau217 capture very early Aβ changes, showing promise as a marker to enrich a preclinical population for AD trials

We thank the ALFA project participants and relatives without whom this research would have not been possible. Collaborators of the ALFA study are: M. Akinci, F. Anastasi, A. Beteta, R. Cacciaglia, A. Cañas, M. Del Campo, C. Deulofeu, I. Cumplido, R. Dominguez, M. Emilio, C. Falcon, S. Fuentes, O. Grau-Rivera, L. Hernandez, G. Huesa, J. Huguet, E. M. Arenaza-Urquijo, P. Marne, T. Menchón, G. Operto, C. Peña-Gómez, E. Palpatzis, A. Polo, B. Rodríguez-Fernández, W.

Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III, Madrid, Spain

 

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