To summarise the clinical features of MPX reported in currently available observational studies.To examine the outcome of MPX cases, including the proportion of patients requiring hospitalisation and those with fatal outcomes.This protocol follows the recommendations established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement [
], and it has been reported in the International Prospective Register of Systematic Reviews database .A comprehensive search about the prevalence of clinical manifestations, characteristics of the lesions and complications of patients diagnosed with monkeypox was conducted on June 7, 2022, through the following databases: PubMed, Scopus, Embase, Ovid-Medline and Web of Science. No restrictions regarding language or publication date were applied.
All the articles resulting from the electronic search were exported to the data management software “Rayyan QCRI”, and duplicate records were removed. Titles and abstracts were independently screened by four reviewers . After identifying the potential references to be included, the reviewers independently assessed the full text of each article. Conflicts or discrepancies in decisions were resolved through debate among the total of the authors, then a consensus was reached.