Previous research has suggested a correlation between HSV-1 and AD and involvement of VZV. However, the sequence of events that the viruses create to set the disease in motion has been unclear.
The investigators found that HSV-1 infection of hiNSCs induces amyloid-beta and P-tau accumulation: the main components of AD plaques and neurofibrillary tangles, respectively. This suggests that VZV is unlikely to be a direct cause of AD but rather acts indirectly via reactivation of HSV-1, they add."It's a one-two punch of two viruses that are very common and usually harmless, but the lab studies suggest that if a new exposure to VZV wakes up dormant HSV-1, they could cause trouble," Cairns said.
"This is preliminary work that first needs replication, validation, and further development to understand if any association that is uncovered between viruses and Alzheimer's/dementia has a mechanistic link," said Snyder. However,"the COVID-19 pandemic has created an opportunity to examine and investigate the relationships between different viruses and Alzheimer's and other dementias by following individuals in more common and well-established ways," she added.
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