with RNA virus infection. They discovered that αSyn is required for neuronal expression of interferon-stimulated genes . They then found that following any stimulus that triggers interferon signals, a type of immune response, αSyn interacts with signaling proteins in neurons to trigger expression of ISGs.
This work provides the first clear mechanism that links inflammation and aSyn, a protein that is closely associated with development of Parkinson's disease. The authors mention that this data confirms that αSyn responds to infection and inflammatory pathways and suggest that this interaction may play an important role in the development of Parkinson's disease. The next important step is to determine if the interactions between interferon and αSyn trigger the formation of the toxic forms of misfolded αSyn, called fibrils, that have been found in Parkinson's disease.
The researchers suggest future studies are needed to look into the interactions between type 1 interferon signals in neurons and misfolded αSyn to determine if drugs that inhibit these interactions can prevent the formation of misfolded αSyn. This would result in a potential disease-modifying therapeutic approach that is needed for patients.
CUAnschutz Parkinson disease is heriditary or genetically inherited.Some are acquired through eating crop roots like carrot that are sprayed with inorganic/ synthetic fertilizer like urea, CO( NH2)2.
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