Microscopic image of prostate cancer that has spread to a patient’s lymph node. Credit: Netherlands Cancer InstituteHormone treatment is successful at controlling metastatic prostate cancer, but the tumor cells eventually develop resistance to it. An unexpected potential solution has now emerged in medicines that are not designed to fight cancer, but rather to target proteins that regulate a cell’s circadian rhythm.
Anti-hormonal therapy can keep prostate cancer under control for a time, but eventually, the cancer manages to progress despite ongoing treatment. The tumor cells have become resistant. This means that the greatest challenge in treating metastatic prostate cancer isn’t to find drugs that inhibit tumor growth itself, but to find drugs that can prevent resistance to hormonal therapy. The exact process of how tumor cells become resistant to hormone therapy, however, has been a mystery — until now.
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