More kids are ingesting melatonin. Here’s what parents should know.

But even the research team, which was made up of pediatricians and toxicologists, was surprised by the results: From January 2012 through December 2021, the annual number of pediatric ingestions of melatonin reported to poison control centers across the United States rose a whopping 530 percent, with a total of 260,435 ingestions reported over that time.

While the ICU cases and deaths are concerning, “We at this time are not asserting that melatonin directly led to serious outcomes, including death,” Vohra said, because of the limitations of poison center data and the lack of individual case narrative reviews.“We don’t want to set off alarm bells among parents, since the majority of melatonin ingestions are relatively benign and resolve without complications,” Vohra said.

“I think we need to look at the data more,” Osterhoudt said. “And we still have to define how big of a dose is dangerous, and if there are any people who might be at particular risk.”“I think that this is the sort of data, where you’re actually getting into hospitalizations and fatalities, that I think underlines the importance of this issue,” said Craig Canapari, a pediatrician and director of the Yale Pediatric Sleep Center.

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