statementEuropean countries have reported a majority of the cases, with 222 probable cases reported in the United Kingdom and Northern Ireland. Cases were also reported in North America, Argentina, the Western Pacific, Southeast Asia and the eastern Mediterranean region.
According to data on the cases in Europe, 75% of the children were under the age of 5. Of the 181 cases tested for adenovirus, 60% were positive. Of the 188 cases tested for COVID-19, 12% were positive. And of the 63 cases that had data on COVID vaccination, 84% were unvaccinated. In this outbreak of severe acute hepatitis, cases have been more severe and "a higher proportion develops acute liver failure compared with previous reports of acute hepatitis of unknown aetiology in children," WHO said.
"While adenovirus is a plausible hypothesis as part of the pathogenesis mechanism, further investigations are ongoing for the causative agent; adenovirus infection does not fully explain the more severe clinical picture observed with these cases," WHO said.
The cause of the outbreak remains under investigation, and WHO classifies the global risk level as moderate.feverfatigueloss of appetitenauseavomitingabdominal paindark urinelight-colored stools joint painjaundice
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