Malaysian scientists create ARiCa for Asian women to determine likelihood of inheriting faulty BRCA gene for prevention of cancer | Malay Mail

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Malaysian scientists create ARiCa for Asian women to determine likelihood of inheriting faulty BRCA gene for prevention of cancer

PETALING JAYA, March 29 — For the longest time, Asian women were unable to get an accurate picture of their breast cancer diagnosis and suitable treatment plans to prevent cancer.

With proper BRCA gene testing, patients are able to get proper medical treatments and more effective therapies to help prevent cancer. — Picture by Cancer Research Malaysia ARiCa uses patient information, such as age of onset of breast cancer, pathology information, and family history of cancer, to generate personalised likelihood score of being a BRCA carrier.Individuals who have a high score are recommended to attend genetic counselling, and if they wish, they can proceed with a genetic test, which is typically conducted using either blood or saliva samples.

In 2013, Angelina Jolie underwent a prophylactic double mastectomy — surgery in which both breasts are removed — after knowing that she carries a faulty BRCA1 gene which would increase the risk of her getting breast and ovarian cancers. “This makes Asian women who are diagnosed with breast cancer and their family members miss out on the opportunity of being aware of their genetic risk status, thereby losing the possibility for cancer prevention and accurate treatment selection.

UM Cancer Research Institute head Dr Nur Aishah Mohd Taib said that prophylactic surgery and targeted therapy may not be routinely available in government-funded and public hospitals, but knowing the BRCA mutation status was important for patients and family members.

 

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