reduced mobility
, research suggests that those with muscle wasting resulting from PAD often have certain mitochondrial abnormalities within the affected leg tissue. These abnormalities are believed to cause oxidative stress, reduce calcium retention, and enhance cell death, researchers explain.
Overall, PAD patients have a high risk of dying from cardiovascular causes. In fact, those with severe limb ischemia—the kind that's known to cause muscle wasting—has been linked with astudy further note that"muscle function is a strong predictor of mortality." This makes it crucial to get a PAD screening if you notice that your leg muscles are becoming weak or feel like they're wasting away. There are several treatment options available, which can improve your health and quality of life. Talking to your doctor or medical provider is the first step.