A fourth COVID-19 shot might be recommended this fall, as officials 'continually' look at emerging data

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As the world approaches the second anniversary of the declaration of the COVID-19 pandemic by the WHO on March 11, more nations are rolling out — or are discussing the possibility of — fourth doses of coronavirus vaccine for their most vulnerable.

In the United States, leading public health officials say they are"very carefully" monitoring if or when fourth doses might be needed.

Now, the US Food and Drug Administration"is indeed continually looking at the emerging data on the pandemic and variants in the United States and overseas in order to evaluate the potential utility and composition of booster doses," FDA spokesperson Alison Hunt wrote in an email to CNN on Friday. If or when the FDA authorizes a fourth dose for the public, the next step would be for the US Centers for Disease Control and Prevention to review the data before making a recommendation for use, as the agency has done for other coronavirus vaccine recommendations.The United States has seen significant improvements recently in COVID-19 cases, hospitalizations and deaths.

"For the immunocompetent people, a single booster shot continues to provide high levels of protection against severe disease caused by Omicron," Fauci said Wednesday."This should not be confused with the fact that for many immunocompromised people, already a second booster shot -- namely a fourth dose of an mRNA -- is recommended because of what we know about their poor response to the initial regimen.

A study published by the CDC last week showed that protection against COVID-19 hospitalization and emergency department or urgent care visits is much higher after a third vaccine dose than a second dose but that protection wanes with time.

 

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