Study shows a lower dose of vital TB drug is as effective | Citypress

ious side effects and, for some, it can still last for more than a year and a half and involves taking many different pills every day.

The two trials are uniquely ambitious in that they test a six- to nine-month experimental regimen of just three drugs – bedaquiline, linezolid, and pretomanid – in people with pre-XDR or XDR-TB .The BPaL regimen can thus be seen as an experimental alternative to the WHO’s long regimen and a challenge to the conventional wisdom that at least four drugs are needed to cure DR-TB.

Accordingly, given the lack of evidence from randomised controlled trials on the BPaL regimen and some safety concerns relating to linezolid and pretomanid, it is not surprising that the WHO, for now, still recommends that the BPaL regimen should only be used in “operational research”. Spotlight previously reported on such operational research on the BPaL regimen being done in South Africa. Pretomanid also has not yet been registered by the SA Health Products Regulatory Authority.

“The aim of the trial was to evaluate whether the efficacy of the BPaL regimen could be maintained while reducing a patient’s exposure to linezolid and its associated side effects,” says Dr Francesca Conradie, principal investigator of the ZeNix trial.

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