Dr. Robert Montgomery had several reasons for getting a COVID-19 vaccine as soon as he could.
The medications that prevent rejection of a transplanted organ also block many transplant patients from making protective antibodies.from Johns Hopkins University School of Medicine found that only 17% of transplant recipients had antibodies after their first dose of a COVID-19 vaccine, with an additional 35% responding after two shots.
. And once they figure out who is protected, they need to figure out what to do for people like Montgomery and Nadeem-Baker who aren't.Montgomery's approach was to sign himself up for a clinical trial testing a third vaccine dose. They should take all the precautions the Centers for Disease Control and Prevention recommends for people with no protection, such as continuing to wear masks and socially distance, he said.
A handful of patients already have started getting extra shots – simply showing up at vaccination centers and not admitting that they've already been vaccinated. It would be far safer, Segev said, for them to get that third dose through a clinical trial. He is now looking for volunteers at"It's really important for this to be out there so people know this is happening," he said.
Segev also will look at whether transplant patients who failed to develop a response after two doses of mRNA vaccines – made by Pfizer-BioNTech and Moderna – will fare any better after a booster. Vaccines also generate T cells, often called the soldiers of the immune system, which seem to provide longer-term protection, but there are no commercially available tests to look for them.
For patients with irritable bowel disease, vaccines appear to be safe and to provide about 80% protection, which is lower than for totally healthy people but still good, Melmed said.tracking 1,800 inflammatory bowel disease patients to understand how they react to vaccination. He said it's too soon to know if IBD patients are getting more "breakthrough infections" after vaccination than the general population, but he hasn't seen worse outcomes among his registry members.
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