If it works, the option of getting an injection every two months could provide women with a new way to prevent HIV infection – something that could be particularly empowering for those who are not in a position to negotiate condom use or who, for whatever reason, cannot take pills to prevent HIV infection.
About 3 200 women aged between 18 and 45 will participate in the trial with results expected next year. Eventually, the 600mg injection is given eight weekly once the dosing is established. It sits in the depot and slowly dissipates over the eight-week period.Cabotegravir is in a relatively new class of ARVs called integrase inhibitors .
Cabotegravir long-acting injections can last for four or eight weeks depending on the dose of the injection. “Side effects are very few. Most are around some mild injection site pain and inflammation, which settles down very quickly and was well tolerated by trial participants.”While a safe and effective two-monthly injection would be an important step forward, there are hopes that products might be developed that last even longer.
If it [cabotegravir long-acting] proves to be safe, it will be a major step forward in the fight against this pandemicShe says antiviral agents need to be potent enough so that sufficient active ingredient can be included stably in an implant.
That sentence makes little sense, but yes, this would be wonderful.
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Source: City_Press - 🏆 7. / 72 Read more »