— and brain MRIs, in particular — are quite important in helping us think about co-occurring conditions. And the reason for that is because, as our understanding of the brain improves, we are looking at the brain much more from the perspective of underlying circuits or brain systems. Those brain systems don’t have one-to-one relationships with psychiatric diagnosis but may underlie various conditions.
Some cases of ADHD are purely attributable to genes, but most researchers believe that, in the lion’s share of cases, Studies using animal models have always had an advantage over human studies in that, after animal studies conclude, researchers can see into the rat’s brains via dissection. Now, a detailed multimodal MRI approach allows labs like mine to take on human studies with a similar, heightened ability to see into the brains of our subjects.
My lab wants to be able to compare genetic risk for ADHD with risk induced from prenatal exposures. Another, more quantitative, approach that we’re using is genotyping. This allows us to compare genetic risk for ADHD with risk induced from prenatal exposures. There is a particular genetic profile called the Polygenic Risk Score that tries to quantify the genetic risk for ADHD.
. And we don’t know which of those changes are actually responsible for symptom improvement versus side effects.Again, my lab is approaching this ADHD treatment quandary with MRI technology. In this case, we’re not using MRI to understand what causes ADHD, but instead we’re using MRI to understand how our treatments work, and what we can do to reduce side effects.
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