To Improve Health on Earth, NIH-Funded Tissue Chips Head Into Space

Five tissue chip projects have already completed their first flight, but none have included heart or gut tissues.

The tissue chip project led by researchers at the University of Washington, Seattle and Johns Hopkins University will compare heart tissue grown on Earth with tissue grown in the low-gravity environment of the ISS National Lab over time to assess visible changes to the tissue as well as changes at the molecular level.

The project led by researchers at Emulate, Inc., a biotechnology company, will look at how the cells that line intestines, including immune cells, respond to salmonella bacteria and whether probiotics — such as the bacteria found in yogurt and other foods — protect the gut from infection. These findings could help scientists better understand the impact of low gravity on immune responses, which could lead to new avenues for preventing or treating foodborne infections on Earth.

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