Researchers from Nagoya University Graduate School of Medicine in Japan have successfully treated the skin diseases epidermolytic ichthyosis and ichthyosis with confetti by transplanting genetically healthy skin to inflamed areas. Transplanting healthy skin to inflamed areas has been used as a treatment option for severe burn injuries. They applied this technique from a common disease to rare diseases.
The group led by Lecturer Kana Tanahashi, Prof. Masashi Akiyama, and Associate Prof. Takuya Takeichi realized that revertant somatic recombination could be used for a pioneering therapy. By making grafts called cultured epidermal autografts , which contain genetic mutation corrections that give healthy skin, and grafting these naturally corrected skin cells to affected areas, outbreaks of the disease could be controlled.
Although it was initially successful, 24 weeks after transplantation, all three patients experienced some recurrence of ichthyosis at the transplant sites. The researchers concluded that the best use of the technique is to alleviate symptoms when the disease is severe and to treat local EI symptoms in specific regions that affect quality of life.
Kana Tanahashi, Michihiro Kono, Takenori Yoshikawa, Yuika Suzuki, Masukazu Inoie, Yachiyo Kuwatsuka, Fumie Kinoshita, Takuya Takeichi, Masashi Akiyama.A study has demonstrated that the appearance of ageing skin looks noticeably different compared to younger skin, when examined under polarized laser light. The scientists believe that their new ...
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